Diacylglycerol Lipase


Definition - What does Diacylglycerol Lipase mean?

Also known as DGL, DAGL, or DAG lipase, Diacylglycerol Lipase refers to a primary enzyme involved in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. This lipase’s primary function is to catalyze the hydrolysis of diacylglycerol. As a result, this releases monoacylglycerol and free fatty acid. Agents such as RHC80267 and tetrahydrolipstatin often act as inhibitors.

MaximumYield explains Diacylglycerol Lipase

A lipase’s primary function is to hydrolyze triglycerides into diglycerides, glycerol, fatty acids, and monoglycerides. They can be found in various plants as well as bacteria and molds. Some lipases may be ubiquitous in nature and are easily commercially exploited due to their easy purification process and low cost.

According to Sammour who studied linseed lipases in 2005, acid lipases are quite active with different types of triacylglycerols, but not with mono and diacylglycerol lipases.

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