Chasing the Blues Away: The 8 Best Cannabis Strains for Depression

By Maximum Yield
Published: January 25, 2019 | Last updated: May 25, 2021 09:25:00
Presented by Sunwest Genetics
Key Takeaways

Did you know that medical marijuana can help cure the blues? As in all things cannabis, some strains are going to be more effective than others in treatment. This article lays out a few.

Do you find yourself sinking into winter blues? The darkest, coldest and shortest days of the year can be hard and depressing. If you suffer from clinical depression, you’re more susceptible.


According to the World Health Organization (WHO), 300 million people from around the world have depression. Fifteen percent of the adult population will experience it at some point in their lives. Depression does not discriminate: it can affect anybody and can look different from person to person.

Throughout history, cannabis has been used as an antidepressant, and some recent research suggests that it works. Researchers at the University of Utrecht, for example, found that cannabis activated the endocannabinoid receptors in depressed people, altering their negative responses to emotions and situations. Want to give it a try to see if it'll lift your mood? We have put together a list of eight powerful medical cannabis strains to try. (Note that clinical depression is a serious illness, so please consult a doctor.)


Cannabis Strains For Depression

Blue Dream

Blue Dream is an epic all-around strain that has rightfully earned its place among the West Coast strains hall of fame. It takes you on a spectacular trip—relieves tension and pain, making you mentally alert to experience a pleasant clear-headed euphoria. This sativa-dominant hybrid is certainly one of the ‘go-to’ strains for treating depression, headaches or migraines, muscle aches and menstrual cramps.

Pineapple Express

Pineapple Express, which was created as an homage to the stoner comedy movie starring Seth Rogan, takes you on a jubilant, energized high. Touted as the strain with the happiest of highs, it meshes perfectly with creative endeavors. Pineapple Express is a powerful (and delicious) weapon against depression, anxiety, Post Traumatic Stress Disorder (PTSD), general lethargy and nausea.

Chemdawg cannabis strainChemdog is often used by medicinal marijuana users to treat chronic stress, anxiety, PTSD, and migraines.



Its lineage is shrouded in mystery but Chemdog’s potency is no secret. Its high THC levels make Chemdog an excellent choice for treating stress, pain, anxiety, depression, arthritis, and Attention Deficit Hyperactivity Disorder (ADHD). It is also used for reducing nausea, fighting insomnia, and improving appetite. Chemdog provides relief to those experiencing cachexia or “wasting syndrome.”

Girl Scout Cookies

This hybrid is a favorite among medical users because of its strong anti-inflammatory and mood-boosting properties. Girl Scout Cookies provides pain relief, helps with nausea and appetite loss, and will leave you in good spirits. Its incredible ‘cookie’ taste makes the savory experience even more delightful. What’s not to love about this Cannabis Cup winner?


Read also: The 5 Best High-CBD Cannabis Strains to Grow


Harlequin consistently tops the lists of high CBD strains. Its sativa-leaning tendencies and 5:2 CBD to THC ratio make it a quintessential candidate in treating depression, anxiety, inflammation, migraine, and chronic pain. It lets you function without the cloudiness and psychoactive high. Harlequin is a gentle giant and truly an exquisite genetic masterpiece.

Jack Herer

We think of Jack Herer as the powerhouse cannabis strain with heavy sativa properties. This highly regarded medicinal strain has moderate THC levels coupled with high levels of CDB. It is lauded for its efficacy in treating depression, anxiety and ADHD. It produces a relaxing body buzz, boost of energy, and lucid cerebral effect.

Cheese cannabis strainBe prepared for a case of munchies and couch lock when you smoke Cheese.


Expect happy, relaxed vibes with an insatiable case of the munchies when you consume Cheese. This indica-dominant strain is powerful in treating chronic stress and depression due to its sedative yet uplifting properties. Users reported experiencing a hard-hitting body high and spaced out head high. Be warned, couch lock might follow.

Sour OG

This strain is a cross of two most widely available strains—Sour Diesel and OG Kush. Sour OG is often described as a one-hitter, making it a legend in its own right. It plunges you into a vivid euphoric sativa high then makes you feel like receiving a warm Indica hug. This potent, beautiful hybrid is perfect for curbing stress, depression, anxiety, PTSD and ADHD.

Depression is a serious medical condition that should not be treated without the advice of a medical professional. Speak to a qualified individual, pick the best strain for you, and watch your symptoms go up in smoke.

Read next: Finding Calm: Cannabis and Anxiety


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Written by Maximum Yield | Publisher

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Maximum Yield Inc. is the print and online publisher behind Maximum Yield and Maximum Yield Cannabis magazines. With topics such as cannabis cultivation and consumption, hydroponics and controlled environment cultivation, as well as greenhouse, container, urban, and vertical growing, Maximum Yield is focused on teaching you how to reach your maximum yield by providing informative articles on the latest technologies and plenty of tips and tricks from grow experts.

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